Yes they need them sometimes to activate certain features (that is a really poor explanation, but simple)

While messing with it today I was able to get it to activate "unknown FPU" and 68020 @14mhz with the Total Systems "Gemstart 3.0" drivers (according to the little system info program)  It also tested very close to the same score I got with the radius 25 accelerator.

http://www.3rz.org/mirrors/macdrivermuseum/accel.shtml

http://www.3rz.org/mirrors/macdrivermuseum/accel/gemstart3.sit (the actual link on the page is broken, but I figured it out this is a direct link)

That's the driver that works (somewhat)