A nice possibility you have with plenty of RAM is to use a RAM disk to contain system and application software and to run the beast with virtual memory off, or to use a RAM disk as a scratch disk (for number crunching, graphics manipulation or a software RIP). Top performance!

Btw: please be so kind and share your experience with the rest of us, improving the 68kMLA Wiki -> RAM module test results. This might save some money one needs not spend for known not working combinations.