Disk controler for lisa was designed for 2x Twiggy drives.

When controler was adapted to 3.5inch, the ROM was written only for 1 drive so, even if hardwork should work with 2 drives. The software in ROM will probably not (In fact, it's exacly the bug that has broken lisa emulation in MESS emulator).

Maybe some version of rom will work (you can test with 800kb roms...)