If you're going to use the hard drive with the Plus exclusively, you're best to format it with an interleave of 3:1, which you can do in Hard Disk Toolkit, or I'd imagine most 3rd party formatters. If not, provided you format the drive on the Plus, I believe Apple HD SC Setup should do it automatically. Also, the Plus lacks internal termination, so you'll need to consider how you set up your SCSI chain as well. Other than that, its pretty much the same as setting up a SCSI device on any other Mac.