The Mac II has lots of NuBus slots, so I was talking more along the lines of installing a plethora of those cards and attaching a 5.25" drive to each.
That seems possible. There are only eject keystrokes for 2 normal floppy drives.
⌘⇧1 - Eject With Ghost Drive 1
⌘⇧2 - Eject With Ghost Drive 2
⌘⇧3 - Screenshot!
BTW neat trick most of us know - when it asks for a disk to be reinserted and you can't for some reason, hit ⌘+period a bunch of times.