See if you can find a copy of Snooper. It's old but it's an amazing diagnostics utility that could also boot standalone from a floppy. It had a number of SCSI tests including device detection, controller testing and destructive disk testing (doesn't need a valid apple driver or filesystem to do this and IF it does anything then it means that the controller is fine and it can write and read back data on the bus)
Those are fancy cards if you have any hardware that supports GPIB. National Instruments still has the drivers and software available on their website but no, weather or not the card is installed would not affect the machine.