Not to the extent that it would affect tanuki65's situation, though. The relevant issue is the DIP switch configuration - specifically SW1-5 and SW1-6. Both must be ON in order to respond to Ctrl-A. Any other config and you need to do Ctrl-I (that's the capital letter "i") in order to get the prompt, and you don't want to be in that situation.
No matter which way the jumper block is oriented, you can use a null modem cable vs. straight-through cable to compensate correctly for it, so that's not the thing to worry about right now.