If you are referring to OWC's "Legacy" line of SSD's that have an IDE/ATA interface, then yes I do believe they may pose a problem in any Mac. The reason I say that is because when I purchased my OWC Legacy SSD, I also purchased an external 2.5 inch hard drive enclosure that can connect to modern Macs by USB or FireWire. When I put the SSD in that enclosure and connected it to my 2009 iMac by USB and by FireWire, I often had problems reading and writing to it. But when I swapped out to the SSD for a regular 2.5 inch spinning platter hard drive, I could read and write perfectly to that hard drive via USB or FireWire, proving that there was nothing wrong with the external enclosure.

Also keep in mind that my bad experience with OWC's Legacy series SSDs wasn't just an unfortunate rare probem with one bad SSD. I went through three of those Legacy SSDs, and all of them exhibited the same problem. I think this gives strong evidence to the fact that OWC had some serious problems in their IDE interface for that line of drives. Whether they have rectified that problem in their "Legacy" line of SSDs over the past year is not something I cannot comment upon. All I can say is that their SATA line of SSDs works perfectly in modern MacBook Pros. But such is not too surprising in light of the fact that the IDE/ATA interface is very different from the SATA interface.