I tried it the other night... it worked. Specs are '030 @ 50MHz and Micron Xceed internal gray-scale. There are two video modes, large and small. In small mode, the refresh rate was fine and usable, but in large mode, the frame rate dropped significantly. The graphics aren't really optimized for grayscale mode though. Sound played fine.

You can find an official demo copy here: ftp://ftp.idsoftware.com/idstuff/doom/mac/