PageMaker (the first page layout program) and Fontographer (the first illustration program) were written on and for the 128k, 512k and Plus as early as 1984. DTP was rolling bigtime by the release of Illustrator 88, PageMaker 3 and the intro of Aldus FreeHand (based upon Fontographer) . . . all during 1988, which I like to refer to as the dawn of the Service Bureau age.

PageMaker was released in July 1985, and relied on Adobe's PostScript page description language. For output, it used the Apple LaserWriter, a PostScript laser printer. PageMaker for the PC was released in 1986, but by then the Mac was already the de facto DTP platform, with Adobe Illustrator (released in 1987) and Adobe Photoshop (released in 1990) completing the suite of graphic design software.

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http://en.wikipedia.org/wiki/Aldus_Corporation
If Apple didn't know about DTP by the 87-88-89 SE/30, IIcx, IIci product development cycle . . .

. . . but Apple can be kinda dense! :

Speaking of dense . . . the first Mac II with video circuitry (the SE/30 kluge) had dedicated VRAM . . . two products later, the high end IIci comes out with vampire video?????

Dense may not be the word . . .