I was doing some reading last night and The Compaq SystemPro, which is considered the first server class PC, had dual 386/486 CPUs. In fact you could mix them, 486 and a 386.
It used Asymmetric Multiprocessing Processing. Basically the second CPU was an offload engine, there wasn't much OS support for it.
It was expensive, started at $16K in 1989 dollars, that is about $30K in todays dollars. So I can't imagine they sold many of them.