That depends on the RAM itself. I have had Pluses and SEs (along with my Mac IIcx/ci's) with 2 or 3 chip SIMMs, but not all of them worked. Further  more, they have to be matched, as in, if you use 1 2 or 3 chips SIMM, they all have to be 2 or 3 chip SIMMs in the bank (for the Plus and SE, that's 2 SIMMs per bank, 4 for most other machines). By matching, it has to be by the same company, same chips used, same everything.

But again, it does not always work, you would need to test them to see if they would work at all as not all will work. I spend much of last month gathering up all my loose SIMMs, pairing them up, testing them, tagging them and rubber banding them in groups so I know what works with what. I had several 2 and 3 chip SIMMs and about 1/2 of them worked on the LC and LCIII (though the LC III uses a different type of SIMM compared to the LC).