I love my Timbuk2 bags. I've owned three, currently have two (the 2nd-largest messenger bags). I'm skeptical if they would serve me well for my CPU, however, as they have less internal structure than others (and the Waterfield's "standupable" bottom seems better than my constantly-falling-over Timbuk2s).

Man, the Timbuk2 is comfy though. I think I'll go have another look....