Sure, I use my touchpad all the time with a pen. Sharpies work best. My iBook loves it, but it has to be uncapped or else it doesn't move the cursor. Jumbo Sharpies have enough charge to move the cursor without a touchpad, using the pen right on the screen, using special Sharpie-Apple technology. The pens are only like $3! But you have to write "pen15" on your drawing hand with the Jumbo Sharpie for it to work properly.