I prefer good trackpads as a pointing device (I recommend the Alps/Cirque Glidepoint series). Trackpads are space-saving on a small desktop. You can use it without a table, holding it in one hand and pointing with the other hand. The Glidepoint devices work even in dirty environment and can be used wearing examination gloves.

For CAD and picture editing I prefer a trackball with click-lock or an Artpad with pen. The general purpose device of my choice a mouse, still.