I used one of these in the bay of my PowerBook 5300 for a while and I could *swear* that the Iomega driver found it.

I do recall that I needed to use Iomega Guest to load/unload the driver whenever I'd wake the powerbook from sleep. That, combined with the fact that I didn't actually have much use for 100MB floppies that at that time still cost a good deal of money, was sufficient to make me sell it.