Well, electrically, it will work fine, with an SCA -> 40pin SCSI adapter. I've never seen such a beast, but you could make it work with an SCA -> 50pin adapter, and a 50 -> 40pin adapter. However, that's not going to fit inside of a PowerBook.

I suggest a 2.5" SCSI -> IDE bridge (HARD to find, these days), or a 2.5" SCSI -> CF adapter, like http://www.artmix.com/pdffiles/CF_PM_Manual2_203_Eng.pdf.

- Alex