False alarm - I had the adapter board connected though both the ADB and pre-ADB interfaces at the same time. :I That probably didn't help.
I tried it again with just the ADB interface, and it all worked smoothly, keyboard and mouse. Thanks!
I've tried several different Macs now with all the PS/2 devices I have, pre-ADB and ADB, and aside from the occasional problems already mentioned it works great. I give it my official QA sign-off!
Let me know if there's anything else specific you'd like me to test.