I do note that while playing with the sources of Basilisk II, there are ROM patches to make the Mac ROM work on a 68060 CPU. Why? Basilisk II has a native execution mode where it passes the 68k instructions through to the host 68k CPU when it's running on a 68k Unix/Linux platform. Said host can be a 68060, so it patches the ROM to make things behave.
So it's not impossible in software. However, in hardware, good luck
