Umm you'll probably get better performance if you can find a Radius PrecisionColor/PrecisionColorPro/LeMans (LeMans is the best), or a Radius/RasterOps Thunder IV. These cards have good 68K drivers.
The significance of the MacPicasso is that they're the only cards for Nubus PPC Macs with 3D acceleration. Still, the AV/HPV cards of Nubus PPC (33/40Mhz clocks vs. 10Mhz in Nubus) are faster than any Nubus Video Cards for 2D performance.

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Kaye (of MacGurus last time I checked) and I did some testing way back when and posted the results on the PowerWatch forums (which are gone). Our tests were performed in PPC NuBus Macs. Our results were that the MacPicasso and Radius Thunder IV GX (1152, 1360, 1600 and Thunder 24/GT) were pretty much tied as fastest NuBus video card available, BUT they were tops in different categories of MacBench. Also, while they beat out the Apple HPV card in a few categories, by and large the HPV card (goes in the PDS slot) provides the very best video performance on NuBus PPC Macs. The AV card is significantly slower than the HPV card.

So, for your first monitor, make sure your PPC NuBus Mac has an HPV card. If you need another monitor, add a MacPicasso or a Radius Thunder IV GX.