actually, is there a piece of software available which would allow somebody to edit a wiki, or upload one, from their desktop rather than having to do it via the website?

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I don't think that would be feasible. Every wiki is going to be different. There's no way you could tell if what you wrote would work for that wiki without previewing in the wiki. And if you have to do that, you might as well edit on the site too. I suppose you could copy-and-paste from a text editor...but that's an additional step, so I don't see that it makes your life easier.