~~\r~ i T r- _ /_ r - [r 1 I * T M k /- / H1 / E& V*® !4W WELCOME TO THE WORLD OF GADGET PAST AS FUTURE” - Be sure to read this instruction manual before beginning play 4 CONTENTS f — -. . . HOW TO SET UP “GADGET - PAST AS FUTURE’’ For users of Windows 95 3 For users of Macintosh 5 About changing CD-ROM discs 7 ...... . Jtefe. a• - HOW TO OPERATE “GADGET PAST AS FUTURE" Use of the menu screens 9 HOW TO SET UP Use of the cursor 13 * - GADGET PASTAS FUTURE THE WORLD OF “GADGET- PASTAS FUTURE’’ An introduction 17 ... Route map of the Grand Central Railway 19 Gadgets you'll meet on your travels 21 The characters 23 What to do if you get stuck 26 1 CREDITS 27 1 SSI 11 i : : BSI& 1 I Si FOR USERS OF HOW TO SET UP 1. [Setup] and [Play] [Setup] Follow these four steps and Change y…

GALAPAGOS Welcome to Galapagos! Galapagos combines intricate puzzles, beautiful worlds, and revolutionary technology to create a phenomenal game. In five stunning and labyrinthine worlds, Mendel relies on you to adapt and survive. You must manipulate the environment to solve puzzles and coax Mendel through hostile, fantastic, mind-bending worlds. Test your reflexes and your mind as you and Mendel journey through the diverse landscapes of Galapagos. Key Features • First game character with a mind of his own • Advanced adaptive controller technology (NERM™) • Hostile environments with mind-blowing puzzles • Real-time 3-D textured, continuous-motion graphics • Active-panning 3-D stereo sound • Addictive, non-sequential gameplay Minimum System Requirements • 90 MHz PowerPC • System 7 or later • 16MB System RAM, 10 MB available RAM • 10 MB hard-drive space • 640X480, 256 colors • 2x CD ROM Drive • Mouse Installation 1. Double-click the Galapagos CD icon. 2. Double-click the Galapagos Installer icon, then click Continue. The Galapagos Installer dialog box appears. 3. Choose a folder in which to install Galapagos. 4. Click Install. A progress meter is displayed as the files are copied to your hard-drive followed by a Successful Installation confirmation message. Playing the Game The one thing that separates Galapagos from other video games is Mendel–he is a truly autonomous creature. You can’t control him, you can only help him. If you coax Mendel safely from one sector to another, he eventually becomes more confident and assertive. If you repeatedly fail, Mendel shatters and regenerates, gradually becoming more neurotic and cagey. To assist Mendel along his escape route, you must properly manipulate certain game elements that exist in his environment. Experiment by clicking on objects to discover which elements you can affect, and then figure out how to use them to Mendel’s advantage. • To activate/deactivate an element, click it. Study the response and use the element in Mendel’s favor. • You may touch Mendel by clicking on him with the right mouse button in the Windows version, or the mouse button with a key modifier in the Macintosh version. Use this to help coax Mendel when you are trying to make it through a tricky play section. Clicking on Mendel is side specific-clicking on his left side is different than than clicking on his right side. This is not required for game play, but it can be useful. • To access menus and game options, press [ESC] at any time. Time Score The Time screen appears after Mendel passes from one world to another through a dimensional gate. It displays the Time spent in the level and the Total time spent in the game. Save Pad Dialog The Save Pad Dialog allows you to save a game in progress. It can only be accessed by clicking on a Save Pad (Blue, shimmering floor panel) while Mendel is walking on it. When Mendel's body is destroyed and regenerates after saving a game, he will appear on the last save pad , al…

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'The Story J of ~utor t has 6een at feast 20 yea.rs sina you've seen your 9reat-'Uru:fe 'Bertratul, yet tfte nu.ss09e from tfte Ft.is estate was dear-you are tfte sofe Tue fcufi."9 ink on tfte &rittfe yeffow p09es ttffs an incrroi6fe taft, fitp.nnifl9 some sixty yea.rs 090 when. 'Bert first purcfi.asea: tfte &uifdi."9. "J've fowul a (jat.ew191, a 6eneficia.ry of Ft.is will. 'That news was certainly wefcomf, (jat.ewa.y to otfw- worfd's, otftu d'immsions," tfte first for it has 6een rumorm tfi.at 'Uncfe '13ertratu!, reduse tfi.at entry mu{s. "Witfi.in tfus fi.um6[e &uifdi."9 fies more fie was, was a worfd traveler wfi.o Fuu! mru:fe Ft.is fortune wealtfi.1 more rufven.ture, tfi.an any fuuufrecf men cou[cf several tinus over 6y trruli119 in antUiuities at fi.ome ruu! savor. .?lru(, tfte secret is mine a.Cone, to Ue:p or sfi.are." a6rorul. You reruf on, entfi.ra!fecL 'Bert speaks of Ft.is first 'Bu.t tfi.e Cf9acy has tumm out to 6e cfisappointi119. few for191s tfi.r009h tfte 9ate1 into a wor[cf of "fn09ic." J{e Jt is notfi.i119 more tfi.an a century-ofd 6rownstone ofjke cfetai.fs fi.is researcfi. aOOut tfte resion. YOU fea.m. tfi.at ~ 6u.itdi119 in a fess tfi.an cfesira6[e area of tfi.e city. 090, 6efore "civi!iza.tion" ancf settfers ca.me on tfte scene, .'Altfi.o1l9h the 6u.ifdi119 itself is stu.rcfy enDU9fi., atul in tfte focal Jncfian tri6es resa.rcfuf this area as taboo, cfi.ar9ecf 9oocf repair, there is cm air of 11R.9fect a6out it. '.From tfi.e witfi. 5trOfl9 meaicine. mu.sty o[cf attic, dOwn tfi.roU9fi. two stories Jiffecf witfi. an Tuere is more, mucfi. more, a6out tfi.ose "otfi.er incrmi6[e coffection of artifacts, to tfie da.nli., rock-wa[[ec( worfd's. " 'Bert has cfi.ronicfecf Ft.is rufventures, in &rief 6asernent, tfie 6uifdi119 is nwre of a Cia6iCity tfi.an an par09Tapfi.s, tfi.r009fi. tliirty years ruu! a dOun worfd's. asset. Tuere is even a coCfection of references, set in careful 'Ifie 6u.iCc:fi119 (wcf no tenants. 'Uncfe 'Bert's smaCC alpfi.a6etical ord'u. 'Ifi.is reference section is apparently a storefront shop on tfi.e first fioor is tfi.e onCy commercial 9uicfe to ruwtftu wor[cf-or worfd's. Jt has 6een usro often esta6(isfiment in tfi.e 6u.itdi119. 'Ifte crru:kecf atu! peefi119 ert01l9h; tfi.e P09e5 Ft.ere a.re smLJ.d9ecf ancf more Jr09ife tfi.an si9n in tfu wind'ow pr…

Roche Genetics Education Program Teacher Manual as distributed with nature Roche Genetics Education Program — Teacher Manual Roche Genetics Education Program Teacher Manual copyright © Hoffmann-La Roche All rights reserved Permission to duplicate this material is granted for non-profit educational purposes only Contents Roche Genetics Education Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Overview of CD Contents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Unit 1 — Introduction to Genetics: A Journey Through the Cell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Unit 2 — Finding Genes Associated with Diseases: In the Genetics Jungle . . . . . . . . . . . . . . . . . . . . . . . . 3 Unit 3 — Genetics of Common Complex Disorders: The Gene Pool . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Unit 4 — Pharmacogenetics: The Gene Scene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Unit 5 — Ethical, Legal, and Social Issues: Genetics and Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Roche Genetics Education Program — Unit 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Introduction to Genetics: A Journey Through the Cell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Activity 1: Disc Quest . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Student Activity 1: Genetics Revisited – A Basic Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Answer Key — Student Activity 1: Genetics Revisited …